Coordination of activating and inhibitory signals in natural killer cells

被引：44

作者：

Chiesa, S ^{[1
]}

Tomasello, E ^{[1
]}

Vivier, E ^{[1
]}

Vély, F ^{[1
]}

机构：

[1] Univ Mediterranee, Ctr Immunol Marseille Luminy, CNRS, INSERM, F-13288 Marseille 09, France

来源：

MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 04期

关键词：

NK cells; transduction; receptor; activation; inhibition; protein tyrosine kinase; protein tyrosine phosphatase;

D O I：

10.1016/j.molimm.2004.07.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NK cells are equipped with multiple activating and inhibitory cell surface receptors whose engagement regulate NK cell effector function (i.e. cytotoxicity as well as chemokine and cytokine production). Several components (adaptors, effector molecules) that participate to NK cell signalling pathways have been described. Yet, the spatio-temporal organisation of these pathways is still poorly understood. In addition, the mechanisms that integrate several simultaneous input signals in NK cells remain to be elucidated. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：477 / 484

页数：8

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