6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists

被引：24

作者：

Kiselgof, E ^{[1
]}

Tulshian, DB ^{[1
]}

Arik, L ^{[1
]}

Zhang, HT ^{[1
]}

Fawzi, A ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Chem Res, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 08期

关键词：

adenosine; receptor; antagonist; 2-Furanyl; 9-H purin;

D O I：

10.1016/j.bmcl.2005.02.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationships have been investigated through substitutions at the 9-position of the 2-amino-6-(2-furanyl) purine (5) to identify novel and selective A(2A) adenosine receptor antagonists. Several potent and selective antagonists were identified. In particular, compounds 20, 25, and 26 show very high affinity with excellent selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2119 / 2122

页数：4

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