MAGIA, a web-based tool for miRNA and Genes Integrated Analysis

被引：119

作者：

Sales, Gabriele ^{[1
]}

Coppe, Alessandro ^{[1
]}

Bisognin, Andrea ^{[1
]}

Biasiolo, Marta ^{[1
]}

Bortoluzzi, Stefania ^{[1
]}

Romualdi, Chiara ^{[1
]}

机构：

[1] Univ Padua, Dept Biol, I-35121 Padua, Italy

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; MICRORNA; EXPRESSION; PREDICTION; INFORMATION; MECHANISMS; PROTEINS; CANCER; ATLAS; VIEW;

D O I：

10.1093/nar/gkq423

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MAGIA (miRNA and genes integrated analysis) is a novel web tool for the integrative analysis of target predictions, miRNA and gene expression data. MAGIA is divided into two parts: the query section allows the user to retrieve and browse updated miRNA target predictions computed with a number of different algorithms (PITA, miRanda and Target Scan) and Boolean combinations thereof. The analysis section comprises a multistep procedure for (i) direct integration through different functional measures (parametric and non-parametric correlation indexes, a variational Bayesian model, mutual information and a meta-analysis approach based on P-value combination) of mRNA and miRNA expression data, (ii) construction of bipartite regulatory network of the best miRNA and mRNA putative interactions and (iii) retrieval of information available in several public databases of genes, miRNAs and diseases and via scientific literature text-mining. MAGIA is freely available for Academic users at http://gencomp.bio.unipd.it/magia.

引用

收藏

页码：W352 / W359

页数：8

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