Simulation of skin permeability in chitosan membranes

被引：59

作者：

Dureja, H ^{[1
]}

Tiwary, AK ^{[1
]}

Gupta, S ^{[1
]}

机构：

[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 213卷 / 1-2期

关键词：

simulated skin; chitosan membrane; percutaneous permeation; central composite design;

D O I：

10.1016/S0378-5173(00)00666-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To provide an alternative means of evaluating transdermal drug delivery systems, membranes of chitosan were developed. The membranes were prepared by cast-drying method. The effects of chitosan concentration, sodium tripolyphosphate (NaTPP) concentration and crosslinking (CL) time on flux and lag time were studied using central composite design. It was observed that chitosan membrane at a particular composition simulated the permeation of diclofenac sodium through rat skin The mathematical model developed in the present study can be used to simulate the permeation of drugs through different species of animal skins. (C) 2001 Published by Elsevier Science B.V.

引用

页码：193 / 198

页数：6

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