An industrial process for synthesizing lodenosine (FddA)

被引：10

作者：

Izawa, K

Takamatsu, S

Katayama , S

Hirose, N

Kozai, S

Maruyama, T

机构：

[1] Ajinomoto Co Inc, AminoSci Labs, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima, Japan

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

anti-HIV; nucleosides; lodenosine; fluorination; radical reduction;

D O I：

10.1081/NCN-120021951

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two industrial synthetic approaches to Lodenosine (1, FddA, 9-(2,3-dideoxy-2-fluoro-p-D-threo-pentofuranosyl) adenine) via a purine riboside or a purine 3'-deoxyriboside are described. Several novel applications of deoxygenation and fluorination methods are compared considering reaction yields, economy, safety and environmental concerns.

引用

收藏

页码：507 / 517

页数：11

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