Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

被引：102

作者：

Nissanka, APK

Karunaratne, V ^{[1
]}

Bandara, BMR

Kumar, V

Nakanishi, T

Nishi, M

Inada, A

Tillekeratne, LMV

Wijesundara, DSA

Gunatilaka, AAL

机构：

[1] Univ Peradeniya, Dept Chem, Peradeniya, Sri Lanka

[2] Setsunan Univ, Fac Pharmaceut Sci, Nagaotoge, Osaka 57301, Japan

[3] Univ Colombo, Dept Chem, Colombo, Sri Lanka

[4] Royal Bot Gardens, Peradeniya, Sri Lanka

[5] Univ Arizona, Off Arid Land Studies, Bioresources Res Facil, Tucson, AZ 85706 USA

来源：

PHYTOCHEMISTRY | 2001年 / 56卷 / 08期

关键词：

Zanthoxylum tetraspermum; Z; caudatum; Rutaceae; benzophenanthrene alkaloids; 8-acetonyldihydronitidine; 8-acetonyldihydroavicine; antimicrobial; spermicidal; insecticidal;

D O I：

10.1016/S0031-9422(00)00402-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma -dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihyronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：857 / 861

页数：5

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