Links between thyroid hormone action, oxidative metabolism, and diabetes risk?

被引：98

作者：

Crunkhorn, Sarah ^{[1
]}

Patti, Mary-Elizabeth ^{[1
]}

机构：

[1] Joslin Diabet Ctr, Div Res, Boston, MA USA

来源：

THYROID | 2008年 / 18卷 / 02期

关键词：

D O I：

10.1089/thy.2007.0249

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A key phenotype associated with type 2 diabetes in humans is impaired mitochondrial oxidative metabolism in skeletal muscle, a pattern potentially contributing to increased lipid accumulation and impaired metabolic flexibility-in turn, central features of both insulin resistance and diabetes. Since thyroid hormone regulates mitochondrial gene expression and function in skeletal muscle, reductions in T3-mediated transcription may contribute to diabetes-related impairments in oxidative metabolism. We review the evidence for relationships between thyroid hormone action and diabetes risk, and discuss potential mechanisms linking intracellular thyroid hormone availability, thyroid receptor action, and the transcriptional coactivator PGC1 in regulating oxidative metabolism.

引用

收藏

页码：227 / 237

页数：11

相关论文

共 133 条

[1] GLUCOSE-TOLERANCE AND INSULIN-SECRETION IN HYPERTHYROIDISM [J].

ANDERSEN, OO ;

FRIIS, T ;

OTTESEN, B .

ACTA ENDOCRINOLOGICA, 1977, 84 (03) :576-587

[2]

[Anonymous], 2007, DIABETES CARE, DOI DOI 10.2337/DC07-S004

[3] Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism -: A novel regulatory mechanism altered in obesity [J].

Bach, D ;

Pich, S ;

Soriano, FX ;

Vega, N ;

Baumgartner, B ;

Oriola, J ;

Daugaard, JR ;

Lloberas, J ;

Camps, M ;

Zierath, JR ;

Rabasa-Lhoret, R ;

Wallberg-Henriksson, H ;

Laville, M ;

Palacín, M ;

Vidal, H ;

Rivera, F ;

Brand, M ;

Zorzano, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17190-17197

[4]

Barbe P, 2001, FASEB J, V15, P13

[5] Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension [J].

Barroso, I ;

Gurnell, M ;

Crowley, VEF ;

Agostini, M ;

Schwabe, JW ;

Soos, MA ;

Maslen, GL ;

Williams, TDM ;

Lewis, H ;

Schafer, AJ ;

Chatterjee, VKK ;

O'Rahilly, S .

NATURE, 1999, 402 (6764) :880-883

[6] Deiodinases: implications of the local control of thyroid hormone action [J].

Bianco, Antonio C. ;

Kim, Brian W. .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (10) :2571-2579

[7] TISSUE-SPECIFIC REGULATION OF FATTY-ACID SYNTHESIS BY THYROID-HORMONE [J].

BLENNEMANN, B ;

MOON, YK ;

FREAKE, HC .

ENDOCRINOLOGY, 1992, 130 (02) :637-643

[8] Projection of diabetes burden through 2050 - Impact of changing demography and disease prevalence in the US [J].

Boyle, JP ;

Honeycutt, AA ;

Narayan, KMV ;

Hoerger, TJ ;

Geiss, LS ;

Chen, H ;

Thompson, TJ .

DIABETES CARE, 2001, 24 (11) :1936-1940

[9] INSULIN-COUNTERACTING HORMONES - THEIR IMPACT ON GLUCOSE-METABOLISM [J].

BRATUSCHMARRAIN, PR .

DIABETOLOGIA, 1983, 24 (02) :74-79

[10] Role of brain insulin receptor in control of body weight and reproduction [J].

Brüning, JC ;

Gautam, D ;

Burks, DJ ;

Gillette, J ;

Schubert, M ;

Orban, PC ;

Klein, R ;

Krone, W ;

Müller-Wieland, D ;

Kahn, CR .

SCIENCE, 2000, 289 (5487) :2122-2125

← 1 2 3 4 5 6 7 8 9 10 →