Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans

被引：93

作者：

Lasala, F

Arce, E

Otero, JR

Rojo, J

Delgado, R

机构：

[1] CSIC, Inst Invest Quim, Grp Carbohidratos, Seville 41092, Spain

[2] Hosp Univ 12 Octubre, Microbiol Serv, Mol Microbiol Lab, Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 12期

关键词：

D O I：

10.1128/AAC.47.12.3970-3972.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

引用

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页码：3970 / 3972

页数：3

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