Fetal growth restriction: adaptations and consequences

被引:205
作者
McMillen, IC [1 ]
Adams, MB
Ross, JT
Coulter, CL
Simonetta, G
Owens, JA
Robinson, JS
Edwards, LJ
机构
[1] Univ Adelaide, Dept Physiol, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Dept Obstet & Gynaecol, Adelaide, SA 5005, Australia
[3] Univ New S Wales, Sch Physiol & Pharmacol, Sydney, NSW 2052, Australia
[4] Univ Alberta, Perinatal Res Ctr, Edmonton, AB, Canada
关键词
D O I
10.1530/rep.0.1220195
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A range of pathophysiological factors can result in a perturbation or restriction of fetal growth, and the cardiovascular, neuroendocrine and metabolic adaptations of the fetus to these stimuli will depend on their nature, timing and intensity. The critical importance of these physiological adaptations for both immediate survival and long-term health outcomes has provided an impetus for experimental studies of the nature and consequences of specific fetal adaptations to a poor intrauterine environment. This review summarizes data from recent studies that have focused on the responses of the fetal cardiovascular, sympathoadrenal, hypothalamo-pituitary-adrenal and renin-angiotensin systems to experimental restriction of placental function in the sheep and discusses the consequences of these adaptations for fetal, neonatal and adult health.
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收藏
页码:195 / 204
页数:10
相关论文
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