Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system

被引：39

作者：

Ehlers, MD ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 01期

关键词：

D O I：

10.1016/j.tins.2003.10.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The active process by which axons degenerate has been shown to require the ubiquitin-proteasome system. A new study reveals potential linkage between the cellular protein degradation machinery and axon loss in neurodegeneration and injury.

引用

页码：3 / 6

页数：4

共 35 条

[1] Ubiquitin, cellular inclusions and their role in neurodegeneration [J].

Alves-Rodrigues, A ;

Gregori, L ;

Figueiredo-Pereira, ME .

TRENDS IN NEUROSCIENCES, 1998, 21 (12) :516-520

[2] Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation [J].

Campbell, DS ;

Holt, CE .

NEURON, 2001, 32 (06) :1013-1026

[3] Deubiquitinating enzymes: Their diversity and emerging roles [J].

Chung, CH ;

Baek, SH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 266 (03) :633-640

[4] Axon pathology in neurological disease: a neglected therapeutic target [J].

Coleman, MP ;

Perry, VH .

TRENDS IN NEUROSCIENCES, 2002, 25 (10) :532-537

[5] Kin I kinesins are microtubule-destabilizing enzymes [J].

Desai, A ;

Verma, S ;

Mitchison, TJ ;

Walczak, CE .

CELL, 1999, 96 (01) :69-78

[6] Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system [J].

Ehlers, MD .

NATURE NEUROSCIENCE, 2003, 6 (03) :231-242

[7] Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease [J].

Ferri, A ;

Sanes, JR ;

Coleman, MP ;

Cunningharn, JM ;

Kato, AC .

CURRENT BIOLOGY, 2003, 13 (08) :669-673

[8]

Finn JT, 2000, J NEUROSCI, V20, P1333

[9] Going new places using an old MAP: tau, microtubules and human neurodegenerative disease [J].

Garcia, ML ;

Cleveland, DV .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (01) :41-48

[10]

GEORGE EB, 1995, J NEUROSCI, V15, P6445

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