Association between PTPN22 and endometriosis

被引:24
作者
Ammendola, Maria [2 ]
Bottini, Nunzio [3 ,4 ]
Pietropolli, Adalgisa [2 ]
Saccucci, Patrizia [1 ]
Gloria-Bottini, Fulvia [1 ]
机构
[1] Hosp Univ Rome Tor Vergata, Dept Biopathol & Imaging Diagnost, Div Human Populat Biopathol & Environm Pathol, Sch Med, Rome, Italy
[2] Hosp Univ Rome Tor Vergata, Div Obstet & Gynecol, Dept Surg, Sch Med, Rome, Italy
[3] Univ So Calif, Dept Orthoped Surg, Los Angeles, CA USA
[4] Univ So Calif, Inst Med Genet, Los Angeles, CA USA
关键词
D O I
10.1016/j.fertnstert.2007.04.008
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
PTPN22 is currently one of the few known shared-autoimmunity genes and is therefore a candidate marker for endometriosis. Our data show that female carriers of the PTPN22*T variant are significantly more susceptible to endometriosis than controls. (Fertil Steril (c) 2008;89:993-4. (c) 2008 by American Society for Reproductive Medicine.)
引用
收藏
页码:993 / 994
页数:2
相关论文
共 10 条
  • [1] A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    Bottini, N
    Musumeci, L
    Alonso, A
    Rahmouni, S
    Nika, K
    Rostamkhani, M
    MacMurray, J
    Meloni, GF
    Lucarelli, P
    Pellecchia, M
    Eisenbarth, GS
    Comings, D
    Mustelin, T
    [J]. NATURE GENETICS, 2004, 36 (04) : 337 - 338
  • [2] Role of PTPN22 in type 1 diabetes and other autoimmune diseases
    Bottini, Nunzio
    Vang, Torkel
    Cucca, Francesco
    Mustelin, Tomas
    [J]. SEMINARS IN IMMUNOLOGY, 2006, 18 (04) : 207 - 213
  • [3] Elucidating endometrial function in the post-genomic era
    Giudice, LC
    [J]. HUMAN REPRODUCTION UPDATE, 2003, 9 (03) : 223 - 235
  • [4] PTPN22: Setting thresholds for autoimmunity
    Gregersen, Peter K.
    Lee, Hye-Soon
    Batliwalla, Franak
    Begovich, Ann B.
    [J]. SEMINARS IN IMMUNOLOGY, 2006, 18 (04) : 214 - 223
  • [5] Gaining insight into PTPN22 and autoimmunity
    Gregersen, PK
    [J]. NATURE GENETICS, 2005, 37 (12) : 1300 - 1302
  • [6] Recommendations for the design of epidemiologic studies of endometriosis
    Holt, VL
    Weiss, NS
    [J]. EPIDEMIOLOGY, 2000, 11 (06) : 654 - 659
  • [7] Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    Marson, Alexander
    Kretschmer, Karsten
    Frampton, Garrett M.
    Jacobsen, Elizabeth S.
    Polansky, Julia K.
    Maclsaac, Kenzie D.
    Levine, Stuart S.
    Fraenkel, Ernest
    von Boehmer, Harald
    Young, Richard A.
    [J]. NATURE, 2007, 445 (7130) : 931 - 935
  • [8] Treating endometriosis as an autoimmune disease
    Nothnick, WB
    [J]. FERTILITY AND STERILITY, 2001, 76 (02) : 223 - 231
  • [9] Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
    Vang, T
    Congia, M
    Macis, MD
    Musumeci, L
    Orrú, V
    Zavattari, P
    Nika, K
    Tautz, L
    Taskén, K
    Cucca, F
    Mustelin, T
    Bottini, N
    [J]. NATURE GENETICS, 2005, 37 (12) : 1317 - 1319
  • [10] Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis
    Viganó, P
    Lattuada, D
    Somigliana, E
    Abbiati, A
    Candiani, M
    Di Blasio, AM
    [J]. MOLECULAR HUMAN REPRODUCTION, 2005, 11 (10) : 745 - 749