Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains

被引：37

作者：

Kawai, T

Sanjo, H

Akira, S

机构：

[1] Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 6638501, Japan

[2] Japan Sci & Technol Corp, CREST, Nishinomiya, Hyogo 6338501, Japan

来源：

GENE | 1999年 / 227卷 / 02期

关键词：

DAP kinase; GEF; Rho; Trio;

D O I：

10.1016/S0378-1119(98)00605-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We show here the identification of Duet, a novel molecule bearing serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains. The kinase domain of Duet shows a homology to that of DAP kinase that is involved in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay. The DH- and PH-domains are closely related to those of Trio and Kalirin. Duet mRNA is specifically expressed in skeletal muscle. Duet protein was localized to actin-associated cytoskeletal elements. These data suggest a role of Duet in the cytoskeleton-dependent cell function. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：249 / 255

页数：7

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