Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

被引：83

作者：

Cheng, YY ^{[1
]}

Xu, TW

Fu, RQ

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Struct Biol Lab, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 12期

关键词：

polyamidoamine dendrimers; PAMAM; solubility enhancer; ketoprofen;

D O I：

10.1016/j.ejmech.2005.08.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamme (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen. (c) 2005 Published by Elsevier SAS.

引用

页码：1390 / 1393

页数：4

共 15 条

[1]

Charles M. H., 2003, INT J PHARMACEUT, V261, P165

[2]

Claudia V, 2000, FARMACO, V63, P165

[3] Ketoprofen sodium: Preparation and its formation of mixed crystals with ketoprofen [J].

Hildebrand, GE ;

MullerGoymann, CC .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (07) :854-857

[4] Solid dispersion of ketoprofen in pellets [J].

Jachowicz, R ;

Nürnberg, E ;

Pieszczek, B ;

Kluczykowska, B ;

Maciejewska, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 206 (1-2) :13-21

[5] Effect of additives on the crystallization and the permeation of ketoprofen from adhesive matrix [J].

Kim, JH ;

Choi, HK .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 236 (1-2) :81-85

[6] Binding of ketoprofen enantiomers in various human albumin preparations [J].

Lagrange, F ;

Péhourcq, F ;

Matoga, M ;

Bannwarth, B .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (05) :793-802

[7]

Makiko F, 2000, INT J PHARMACEUT, V205, P117

[8] CHEMISTRY OF MICELLES .13. UNIMOLECULAR MICELLES [J].

NEWKOME, GR ;

MOOREFIELD, CN ;

BAKER, GR ;

SAUNDERS, MJ ;

GROSSMAN, SH .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (09) :1178-1180

[9]

Simon J., 2003, INT J PHARMACEUT, V268, P37

[10]

Tomalia D. A., 1986, U.S. Patent, Patent No. [4587329, 4,587,329]

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