Compartmentalization of regulatory proteins in the cell nucleus

被引：37

作者：

Hendzel, MJ

Kruhlak, MJ

MacLean, NAB

Boisvert, FM

Lever, MA

Bazett-Jones, DP

机构：

[1] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

[2] Univ Alberta, Fac Med & Dent, Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada

[3] Univ Calgary, Fac Med, Dept Cell Biol & Anat, Calgary, AB T2N 4N1, Canada

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2001年 / 76卷 / 1-5期

关键词：

cell nucleus; regulatory proteins; genomic DNA;

D O I：

10.1016/S0960-0760(00)00153-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of proteins involved in the regulation of RNA polymerase II-transcribed genes is then discussed. Finally, very recent data on the mobility of these proteins within the cell nucleus is considered and their implications for regulation through compartmentalization of proteins and genomic DNA are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：9 / 21

页数：13

共 123 条

[1] Chromatin dynamics in interphase nuclei and its implications for nuclear structure [J].