Anti-leukemic and anti-GVHD effects of campath-1H in acute lymphoblastic leukemia relapsed after stem-cell transplantation

被引：16

作者：

Piccaluga, PP

Martinelli, G

Malagola, M

Rondoni, M

Bianchini, M

Vigna, E

Bosi, C

Gaitani, S

Visani, G

Baccarani, M

机构：

[1] Univ Bologna, S Orsola Malpighi Hosp, Inst Haematol & Med Oncol L&A Seragnoli, I-40126 Bologna, Italy

[2] S Salvatore Hosp, Dept Haematol, Pesaro, Italy

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 04期

关键词：

acute lymphoblastic leukemia; monoclonal antibodies; campath-1H; stem cell transplantation; graft vs. host disease;

D O I：

10.1080/10428190310001603948

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite aggressive approaches, including second transplant, donor lymphocyte infusion and several new agents, the prognosis of acute lymphoid leukemia ( ALL) patients relapsing after stem- cell transplantation ( SCT) remains poor. Monoclonal- antibodies ( moAb) could provide a useful tool in this setting. In particular, anti- CD52 moAb is useful in lymphoid malignancies. We thus treated as compassionate with campath- 1H 3 ALL patients relapsed after SCT. In 2 cases we observed a reduction of peripheral blood and/ or bone marrow blasts. In 1 case a GVHD grade reduction was observed. Larger trials are required in order to define the role of campath- 1H in ALL.

引用

页码：731 / 733

页数：3

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