Alkylation of 1-alkynes in THF

被引：40

作者：

Buck, M ^{[1
]}

Chong, JM ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 34期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)01131-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynes may be easily alkylated by sequential treatment with n-BuLi followed by an alkyl halide in THF. Primary iodides give excellent yields (75-99%) as do bromides in the presence of catalytic amounts of Bu4NI or NaI; in the absence of an iodide source, bromides react poorly. This method offers advantages over existing methods which use HMPA or NH3 as co-solvents. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：5825 / 5827

页数：3

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