Chromogranin A levels and mortality in patients with severe sepsis

被引：14

作者：

Hsu, Chih-Hsin ^{[1
,2
]}

Reyes, Luis F. ^{[1
,2
,3
]}

Orihuela, Carlos J. ^{[1
]}

Buitrago, Ricardo ^{[3
,4
]}

Anzueto, Antonio ^{[1
,2
]}

Soni, Nilam J. ^{[1
,2
]}

Levine, Stephanie ^{[1
,2
]}

Peters, Jay ^{[1
,2
]}

Hinojosa, Cecilia A. ^{[1
]}

Aliberti, Stefano ^{[5
]}

Sibila, Oriol ^{[6
]}

Rodriguez, Alejandro ^{[7
,8
]}

Chalmers, James D. ^{[9
]}

Martin-Loeches, Ignacio ^{[10
]}

Bordon, Jose ^{[11
]}

Blanquer, Jose ^{[12
]}

Sanz, Francisco ^{[13
]}

Marcos, Pedro J. ^{[14
]}

Rello, Jordi ^{[15
]}

Sole-Violan, Jordi ^{[16
]}

Restrepo, Marcos I. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[2] South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA

[3] Univ Sabana, Bogota, Colombia

[4] Clin Shaio, Bogota, Colombia

[5] Univ Milano Bicocca, Clin Pneumol, Monza, Italy

[6] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Med, Serv Pneumol, E-08193 Barcelona, Spain

[7] Joan XXIII Univ Hosp, Crit Care Dept, Tarragona, Spain

[8] CIBERES, Pere Virgili Hlth Inst, Tarragona, Spain

[9] Univ Dundee, Dundee, Scotland

[10] St James Hosp, Trinity Ctr Hlth Sci, CIBERES, Dublin 8, Ireland

[11] Providence Hosp, Dept Med, Infect Dis Sect, Washington, DC USA

[12] Hosp Clin Univ, Unidad Cuidados Intens Resp, Valencia, Spain

[13] Consorci Hosp Gen Univ Valencia, Dept Pulmonol, Valencia, Spain

[14] Univ Coruna UDC, Sergas, CHUAC, Serv Neumol,Inst Invest Biomed A Coruna INIBIC, La Coruna, Spain

[15] Hosp Univ Vall dHebron, CIBERES, Crit Care Dept, Barcelona, Spain

[16] Hosp Univ Dr Negrin, CIBERES, Intens Care Unit, Las Palmas Gran Canaria, Spain

来源：

BIOMARKERS | 2015年 / 20卷 / 03期

关键词：

Biological marker; cardiovascular diseases; Chromogranin A; mortality; sepsis; PROGNOSTIC VALUE; EPIDEMIOLOGY; BIOMARKER; ADMISSION;

D O I：

10.3109/1354750X.2015.1046932

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Context: Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis. Objective: Assess association of CgA levels and mortality risk of severely septic patients. Methods: Serum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h. Results: Higher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01. Conclusions: High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

引用

页码：171 / 176

页数：6

共 21 条

[1]

Critical Care 1 Critical care and the global burden of critical illness in adults [J].

Adhikari, Neill K. J. ;

Fowler, Robert A. ;

Bhagwanjee, Satish ;

Rubenfeld, Gordon D. .

LANCET, 2010, 376 (9749) :1339-1346

[2]

Chromogranin-A: A Multifaceted Cardiovascular Role in Health and Disease [J].

Angelone, T. ;

Mazza, R. ;

Cerra, M. C. .

CURRENT MEDICINAL CHEMISTRY, 2012, 19 (24) :4042-4050

[3]

Current epidemiology of septic shock - The CUB-Rea network [J].

Annane, D ;

Aegerter, P ;

Jars-Guincestre, MC ;

Guidet, B .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (02) :165-172

[4]

[Anonymous], CRIT CARE MED

[5]

PROCALCITONIN LEVELS IN SURVIVORS AND NONSURVIVORS OF SEPSIS: SYSTEMATIC REVIEW AND META-ANALYSIS [J].

Arora, Shubhangi ;

Singh, Prashant ;

Singh, Preet Mohinder ;

Trikha, Anjan .

SHOCK, 2015, 43 (03) :212-221

[6]

DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].

BONE, RC ;

BALK, RA ;

CERRA, FB ;

DELLINGER, RP ;

FEIN, AM ;

KNAUS, WA ;

SCHEIN, RMH ;

SIBBALD, WJ .

CHEST, 1992, 101 (06) :1644-1655

[7]

Unravelling post-ICU mortality: predictors and causes of death [J].

Braber, Annemarije ;

van Zanten, Arthur R. H. .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2010, 27 (05) :486-490

[8]

Biological function and clinical relevance of chromogranin A and derived peptides [J].

D'amico, Maria Angela ;

Ghinassi, Barbara ;

Izzicupo, Pascal ;

Manzoli, Lamberto ;

Di Baldassarre, A. .

ENDOCRINE CONNECTIONS, 2014, 3 (02) :R45-R54

[9]

Dellinger RP, 2013, INTENS CARE MED, V41, P580, DOI [DOI 10.1097/CCM.0B013E31827E83AF, DOI 10.1007/s00134-012-2769-8]

[10]

Soluble urokinase-type plasminogen activator receptor as a prognostic biomarker in critically ill patients [J].

Donadello, Katia ;

Scolletta, Sabino ;

Taccone, Fabio Silvio ;

Covajes, Cecilia ;

Santonocito, Cristina ;

Cortes, Diego Orbegozo ;

Grazulyte, Daiva ;

Gottin, Leonardo ;

Vincent, Jean-Louis .

JOURNAL OF CRITICAL CARE, 2014, 29 (01) :144-149

← 1 2 3 →