Acute graft pyelonephritis: A potential cause of acute rejection in renal transplant

被引：48

作者：

Audard, V ^{[1
]}

Amor, M ^{[1
]}

Desvaux, D ^{[1
]}

Pastural, M ^{[1
]}

Baron, C ^{[1
]}

Philippe, R ^{[1
]}

Pardon, A ^{[1
]}

Dahmane, D ^{[1
]}

Lang, P ^{[1
]}

Grimbert, P ^{[1
]}

机构：

[1] Hop Henri Mondor, Dept Nephrol & Transplantat, Serv Nephrol, F-94010 Creteil, France

来源：

TRANSPLANTATION | 2005年 / 80卷 / 08期

关键词：

danger signal; bacterial infection; dendritic cells; alloimune response;

D O I：

10.1097/01.TP.0000174343.05590.9F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute graft pyelonephritis is a common complication in renal transplant recipients. The consequences of this complication on kidney allograft survival remain controversial. Bacterial infection is likely to activate the immune system, potentially leading to acute or chronic rejection. Here, we report for the first time two documented cases of acute rejection occurring shortly after acute graft pyelonephritis, suggesting that pyelonephritis can initiate acute rejection. The immunologic process leading to the alloimmune response is discussed. These reports suggest that acute rejection should be questioned in case of atypical graft outcome in the context of acute graft pyelonephritis.

引用

页码：1128 / 1130

页数：3

共 15 条

[1] Late urinary tract infection after renal transplantation in the United States [J].

Abbott, KC ;

Swanson, SJ ;

Richter, ER ;

Bohen, EM ;

Agodoa, LY ;

Peters, TG ;

Barbour, G ;

Lipnick, R ;

Cruess, DF .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 44 (02) :353-362

[2] Signaling danger:: Toll-like receptors and their potential roles in kidney disease [J].

Anders, HJ ;

Banas, B ;

Schlöndorff, D .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (04) :854-867

[3] Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2 [J].

Biragyn, A ;

Ruffini, PA ;

Leifer, CA ;

Klyushnenkova, E ;

Shakhov, A ;

Chertov, O ;

Shirakawa, AK ;

Farber, JM ;

Segal, DM ;

Oppenheim, JJ ;

Kwak, LW .

SCIENCE, 2002, 298 (5595) :1025-1029

[4] Role of toll-like receptor 4 in endotoxin-induced acute renal failure [J].

Cunningham, PN ;

Wang, Y ;

Guo, RQ ;

He, G ;

Quigg, RJ .

JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2629-2635

[5] Acute graft pyelonephritis and long-term kidney allograft outcome [J].

Giral, M ;

Pascuariello, G ;

Karam, G ;

Hourmant, M ;

Cantarovich, D ;

Dantal, J ;

Blancho, G ;

Coupel, S ;

Josien, R ;

Daguin, P ;

Méchineau, S ;

Soulillou, JP .

KIDNEY INTERNATIONAL, 2002, 61 (05) :1880-1886

[6] Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection [J].

Goldstein, DR ;

Tesar, BM ;

Akira, S ;

Lakkis, FG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (10) :1571-1578

[7] The evolving role of chemokines and their receptors in acute allograft rejection [J].

Inston, NG ;

Cockwell, P .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 (08) :1374-1379

[8] ELEVATED INTERLEUKIN-8 LEVELS IN THE URINE OF PATIENTS WITH URINARY-TRACT INFECTIONS [J].

KO, YC ;

MUKAIDA, N ;

ISHIYAMA, S ;

TOKUE, A ;

KAWAI, T ;

MATSUSHIMA, K ;

KASAHARA, T .

INFECTION AND IMMUNITY, 1993, 61 (04) :1307-1314

[9] Association of cytomegalovirus disease and acute rejection with graft loss in kidney transplantation [J].

Nett, PC ;

Heisey, DM ;

Fernandez, LA ;

Sollinger, HW ;

Pirsch, JD .

TRANSPLANTATION, 2004, 78 (07) :1036-1041

[10] Bactericidal activity of renal tubular cells:: The putative role of human β-defensins [J].

Nitschke, M ;

Wiehl, S ;

Baer, PC ;

Kreft, B .

EXPERIMENTAL NEPHROLOGY, 2002, 10 (5-6) :332-337

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