Prognostic factors in ductal pancreatic cancer

被引:94
作者
Yeo, CJ [1 ]
Cameron, JL [1 ]
机构
[1] Johns Hopkins Hosp, Baltimore, MD 21287 USA
关键词
pancreatic adenocarcinoma; tumor DNA content; p53 tumor suppressor gene; adjuvant chemoradiation therapy;
D O I
10.1007/s004230050104
中图分类号
R61 [外科手术学];
学科分类号
摘要
Introduction: The diagnosis of pancreatic adenocarcinoma remains a devastating life event for most patients and their families. Many patients with this relatively common malignancy present at a stage of disease not amenable to cancer-directed resectional therapy, and are treated via nonoperative palliative measures, with median survival of 4-8 months post-diagnosis. Conclusion: A minority of patients present with disease limited to the pancreas and periampullary region and are candidates for resectional therapy. The prognosis for these patients is determined by several factors: clinicopathologic staging, tumor biology and molecular genetics, perioperative factors and the use of postoperative adjuvant therapy.
引用
收藏
页码:129 / 133
页数:5
相关论文
共 27 条
[1]   PANCREATIC-CANCER CELL-DNA CONTENT CORRELATES WITH LONG-TERM SURVIVAL AFTER PANCREATICODUODENECTOMY [J].
ALLISON, DC ;
BOSE, KK ;
HRUBAN, RH ;
PIANTADOSI, S ;
DOOLEY, WC ;
BOITNOTT, JK ;
CAMERON, JL .
ANNALS OF SURGERY, 1991, 214 (06) :648-656
[2]   ADJUVANT COMBINATION CHEMOTHERAPY (AMF) FOLLOWING RADICAL RESECTION OF CARCINOMA OF THE PANCREAS AND PAPILLA OF VATER - RESULTS OF A CONTROLLED, PROSPECTIVE, RANDOMIZED MULTICENTER STUDY [J].
BAKKEVOLD, KE ;
ARNESJO, B ;
DAHL, O ;
KAMBESTAD, B .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (05) :698-703
[3]   CONVENTIONAL EXTERNAL IRRADIATION ALONE AS ADJUVANT TREATMENT IN RESECTABLE PANCREATIC-CANCER - RESULTS OF A PROSPECTIVE-STUDY [J].
BOSSET, JF ;
PAVY, JJ ;
GILLET, M ;
MANTION, G ;
PELISSIER, E ;
SCHRAUB, S .
RADIOTHERAPY AND ONCOLOGY, 1992, 24 (03) :191-194
[4]  
Brat DJ, 1997, AM J PATHOL, V150, P383
[5]  
Brierley JD, 2016, TNM CLASSIFICATION M
[6]  
DIGIUSEPPE JA, 1996, ADV ANAT PATHOL, V3, P139
[7]  
DOUGLASS HO, 1987, CANCER, V59, P2006
[8]  
GEER RJ, 1993, AM J SURG, V165, P6873
[9]   THE EFFECTS OF REGIONALIZATION ON COST AND OUTCOME FOR ONE GENERAL HIGH-RISK SURGICAL-PROCEDURE [J].
GORDON, TA ;
BURLEYSON, GP ;
TIELSCH, JM ;
CAMERON, JL .
ANNALS OF SURGERY, 1995, 221 (01) :43-49
[10]  
GRIFFIN CA, 1995, CANCER RES, V55, P2394