Complex role of the HIF system in cardiovascular biology

被引：37

作者：

Czibik, Gabor ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Dept Cardiovasc Med, Oxford OX3 9DU, England

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2010年 / 88卷 / 11期

关键词：

HIF; Developmental; Angiogenesis; Hypertension; Energy metabolism; Cardiomyopathy; HYPOXIA-INDUCIBLE-FACTOR; CHRONIC INTERMITTENT HYPOXIA; PULMONARY ARTERIAL MYOCYTES; HYDROXYLASE DOMAIN PROTEINS; PROLYL HYDROXYLASE; TRANSCRIPTION FACTOR; FACTOR; 1-ALPHA; DNA-BINDING; FACTOR-I; CARDIAC-HYPERTROPHY;

D O I：

10.1007/s00109-010-0646-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The hypoxia-inducible factor (HIF) system was discovered as an oxygen-sensitive regulatory pathway that confers adaptive responses to hypoxia. Novel aspects of this growing network indicate that there is a significant, nonhypoxic contribution to regulation. Multiple lines of evidence suggest that components of the HIF pathway are intimately involved in the pathogenesis of cardiovascular disorders. This review highlights the functional context of the HIF system in cardiovascular pathobiology with possible therapeutic implications.

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收藏

页码：1101 / 1111

页数：11

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