Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2

被引:56
作者
Razonable, RR
Henault, M
Lee, LN
Laethem, C
Johnston, PA
Watson, HL
Paya, CV
机构
[1] Mayo Clin & Mayo Fdn, Div Infect Dis & Internal Med, Rochester, MN 55905 USA
[2] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
10.1128/AAC.49.4.1617-1621.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-8. Hence, TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with AmB.
引用
收藏
页码:1617 / 1621
页数:5
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