Autocrine IL-6 signaling: A key event in tumorigenesis?

被引：305

作者：

Grivennikov, Sergei ^{[1
]}

Karin, Michael ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

来源：

CANCER CELL | 2008年 / 13卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2007.12.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumorigenesis is a multistep process that requires constitutive cell division, growth, and survival. One strategy used by cancer cells to upregulate growth and survival pathways is through autocrine production of growth and survival factors. Two recent papers by Gao et al. and Sansone et al. published in The Journal of Clinical Investigation outline the importance of autocrine interleukin 6 (IL-6) in lung and breast cancers and implicate IL-6 as an important activator of oncogenic STAT3 in lung adenocarcinomas and of Jagged-1/Notch signaling in breast tumor mammospheres.

引用

页码：7 / 9

页数：3

共 14 条

[1] Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis [J].

Ancrile, Brooke ;

Lim, Kian-Huat ;

Counter, Christopher M. .

GENES & DEVELOPMENT, 2007, 21 (14) :1714-1719

[2]

Becker C, 2005, CELL CYCLE, V4, P217

[3] Cutting edge:: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+ CD25- T cells [J].

Dominitzki, Sabine ;

Fantini, Massimo C. ;

Neufert, Clemens ;

Nikolaev, Alexei ;

Galle, Peter R. ;

Scheller, Juergen ;

Monteleone, Giovanni ;

Rose-John, Stefan ;

Neurath, Markus F. ;

Becker, Christoph .

JOURNAL OF IMMUNOLOGY, 2007, 179 (04) :2041-2045

[4] Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas [J].

Gao, Sizhi Paul ;

Mark, Kevin G. ;

Leslie, Kenneth ;

Pao, William ;

Motoi, Noriko ;

Gerald, William L. ;

Travis, William D. ;

Bornmann, William ;

Veach, Darren ;

Clarkson, Bayard ;

Bromberg, Jacqueline F. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :3846-3856

[5] The role of IL-6 and STAT3 in inflammation and cancer [J].

Hodge, DR ;

Hurt, EM ;

Farrar, WL .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (16) :2502-2512

[6] Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer [J].

Karin, M ;

Lawrence, T ;

Nizet, V .

CELL, 2006, 124 (04) :823-835

[7] Interleukin-6: From basic science to medicine - 40 years in immunology [J].

Kishimoto, T .

ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 :1-21

[8] Interleukin-6 trans-signaling in inflammatory bowel disease [J].

Mitsuyama, Keiichi ;

Sata, Michio ;

Rose-John, Stefan .

CYTOKINE & GROWTH FACTOR REVIEWS, 2006, 17 (06) :451-461

[9] Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production [J].

Naugler, Willscott E. ;

Sakurai, Toshiharu ;

Kim, Sunhwa ;

Maeda, Shin ;

Kim, KyoungHyun ;

Elsharkawy, Ahmed M. ;

Karin, Michael .

SCIENCE, 2007, 317 (5834) :121-124

[10] STAT-mediated EGFR signaling in cancer [J].

Quesnelle, Kelly M. ;

Boehm, Amanda L. ;

Grandis, Jennifer R. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 102 (02) :311-319

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