5-HT3 receptor antagonists ameliorate fatigue:: so much potential, so little knowledge!

被引：3

作者：

Barnes, NM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Pharmacol,Div Neurosci, Cellular & Mol Neuropharmacol Res Grp, Birmingham B15 2TT, W Midlands, England

来源：

GUT | 2005年 / 54卷 / 08期

关键词：

D O I：

10.1136/gut.2004.063545

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is growing evidence that 5-HT3 receptor blockade will benefit patients with fatigue. Further research is needed to determine the mechanism underlying this widespread clinically important symptom and therapies may be derived from targeting the 5-HT system.

引用

收藏

页码：1056 / 1057

页数：2

相关论文

共 25 条

[1] IDENTIFICATION AND CHARACTERIZATION OF 5-HYDROXYTRYPTAMINE3 RECOGNITION SITES IN HUMAN-BRAIN TISSUE [J].

BARNES, JM ;

BARNES, NM ;

COSTALL, B ;

IRONSIDE, JW ;

NAYLOR, RJ .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (06) :1787-1793

[2] CHARACTERIZATION AND AUTORADIOGRAPHIC LOCALIZATION OF 5-HT3 RECEPTOR RECOGNITION SITES IDENTIFIED WITH [3H]-(S)-ZACOPRIDE IN THE FOREBRAIN OF THE RAT [J].

BARNES, JM ;

BARNES, NM ;

CHAMPANERIA, S ;

COSTALL, B ;

NAYLOR, RJ .

NEUROPHARMACOLOGY, 1990, 29 (11) :1037-&

[3]

BARNES JM, 1991, PHARM J, V246, P112

[4] A review of central 5-HT receptors and their function [J].

Barnes, NM ;

Sharp, T .

NEUROPHARMACOLOGY, 1999, 38 (08) :1083-1152

[5] Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors [J].

Brady, CA ;

Stanford, IM ;

Ali, I ;

Lin, L ;

Williams, JM ;

Dubin, AE ;

Hope, AG ;

Barnes, NM .

NEUROPHARMACOLOGY, 2001, 41 (02) :282-284

[6] DISTRIBUTION AND CHARACTERIZATION OF THE [H-3] GRANISETRON-LABELED 5-HT3 RECEPTOR IN THE HUMAN FOREBRAIN [J].

BUFTON, KE ;

STEWARD, LJ ;

BARBER, PC ;

BARNES, NM .

NEUROPHARMACOLOGY, 1993, 32 (12) :1325-1331

[7] Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635 [J].

Cleare, AJ ;

Messa, C ;

Rabiner, EA ;

Grasby, PM .

BIOLOGICAL PSYCHIATRY, 2005, 57 (03) :239-246

[8] 5-HT3 Receptors [J].

Costall, Brenda ;

Naylor, Robert J. .

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2004, 3 (01) :27-37

[9] The 5-HT3B subunit is a major determinant of serotonin-receptor function [J].

Davies, PA ;

Pistis, M ;

Hanna, MC ;

Peters, JA ;

Lambert, JJ ;

Hales, TG ;

Kirkness, EF .

NATURE, 1999, 397 (6717) :359-363

[10] The pharmacological and functional characteristics of the serotonin 5-HT3A receptor are specifically modified by a 5-MT3B receptor subunit [J].

Dubin, AE ;

Huvar, R ;

D'Andrea, MR ;

Pyati, J ;

Zhu, JY ;

Joy, KC ;

Wilson, SJ ;

Galindo, JE ;

Glass, CA ;

Luo, L ;

Jackson, MR ;

Lovenberg, TW ;

Erlander, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) :30799-30810