Dynamic observation of pulmonary perfusion using continuous arterial spin-labelling in a pig model

被引：12

作者：

Roberts, DA ^{[1
]}

Rizi, RR ^{[1
]}

Lipson, DA ^{[1
]}

Ferrante, MA ^{[1
]}

Bearn, L ^{[1
]}

Rolf, L ^{[1
]}

Baumgardner, J ^{[1
]}

Yamomoto, A ^{[1
]}

Hatabu, H ^{[1
]}

Hansen-Flaschen, J ^{[1
]}

Gefter, WB ^{[1
]}

Schnall, MD ^{[1
]}

机构：

[1] Univ Penn, Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2001年 / 14卷 / 02期

关键词：

pulmonary perfusion; lung; blood flow; spin-tagging; functional MRI;

D O I：

10.1002/jmri.1169

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The continuous arterial spin-labeling (CASL) method of perfusion MRI is used to observe pulmonary perfusion dynamically in an animal model. Specifically, a respiratory-triggered implementation of the CASL method is used with approximate spatial resolution of 0.9 x 1.8 X 5.0 mm (0.008 cc) and 2-minute temporal resolution. Perfusion MRI is performed dynamically during repeated balloon occlusion of a segmental pulmonary artery, as well as during pharmacological stimulation. A total of three Yorkshire pigs were studied. The results demonstrate the ability of the endogenous spin-labeling method to characterize the dynamic changes in pulmonary perfusion that occur during important physiological alterations. (C) 2001 Wiley-Liss, Inc.

引用

页码：175 / 180

页数：6

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