The Spliceosome as an Indicted Conspirator in Myeloid Malignancies

被引：34

作者：

Abdel-Wahab, Omar ^{[1
]}

Levine, Ross ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, Leukemia Serv, New York, NY 10065 USA

来源：

CANCER CELL | 2011年 / 20卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2011.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing.

引用

页码：420 / 423

页数：4

共 10 条

[1]

Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation [J].

Abrahamsson, Annelie E. ;

Geron, Ifat ;

Gotlib, Jason ;

Dao, Kim-Hien T. ;

Barroga, Charlene F. ;

Newton, Isabel G. ;

Giles, Francis J. ;

Durocher, Jeffrey ;

Creusot, Remi S. ;

Karimi, Mobin ;

Jones, Carol ;

Zehnder, James L. ;

Keating, Armand ;

Negrin, Robert S. ;

Weissman, Irving L. ;

Jamieson, Catriona H. M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3925-3929

[2]

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart [J].

Ding, JH ;

Xu, XD ;

Yang, DM ;

Chu, PH ;

Dalton, ND ;

Ye, Z ;

Yeakley, JM ;

Cheng, HP ;

Xiao, RP ;

Ross, J ;

Chen, J ;

Fu, XD .

EMBO JOURNAL, 2004, 23 (04) :885-896

[3]

Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1 [J].

Isono, K ;

Mizutani-Koseki, Y ;

Komori, T ;

Schmidt-Zachmann, MS ;

Koseki, H .

GENES & DEVELOPMENT, 2005, 19 (05) :536-541

[4]

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA [J].

Kaida, Daisuke ;

Motoyoshi, Hajime ;

Tashiro, Etsu ;

Nojima, Takayuki ;

Hagiwara, Masatoshi ;

Ishigami, Ken ;

Watanabe, Hidenori ;

Kitahara, Takeshi ;

Yoshida, Tatsuhiko ;

Nakajima, Hidenori ;

Tani, Tokio ;

Horinouchi, Sueharu ;

Yoshida, Minoru .

NATURE CHEMICAL BIOLOGY, 2007, 3 (09) :576-583

[5]

Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts [J].

Papaemmanuil, E. ;

Cazzola, M. ;

Boultwood, J. ;

Malcovati, L. ;

Vyas, P. ;

Bowen, D. ;

Pellagatti, A. ;

Wainscoat, J. S. ;

Hellstrom-Lindberg, E. ;

Gambacorti-Passerini, C. ;

Godfrey, A. L. ;

Rapado, I. ;

Cvejic, A. ;

Rance, R. ;

McGee, C. ;

Ellis, P. ;

Mudie, L. J. ;

Stephens, P. J. ;

McLaren, S. ;

Massie, C. E. ;

Tarpey, P. S. ;

Varela, I. ;

Nik-Zainal, S. ;

Davies, H. R. ;

Shlien, A. ;

Jones, D. ;

Raine, K. ;

Hinton, J. ;

Butler, A. P. ;

Teague, J. W. ;

Baxter, E. J. ;

Score, J. ;

Galli, A. ;

Della Porta, M. G. ;

Travaglino, E. ;

Groves, M. ;

Tauro, S. ;

Munshi, N. C. ;

Anderson, K. C. ;

El-Naggar, A. ;

Fischer, A. ;

Mustonen, V. ;

Warren, A. J. ;

Cross, N. C. P. ;

Green, A. R. ;

Futreal, P. A. ;

Stratton, M. R. ;

Campbell, P. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (15) :1384-1395

[6]

A comprehensive catalogue of somatic mutations from a human cancer genome [J].

Pleasance, Erin D. ;

Cheetham, R. Keira ;

Stephens, Philip J. ;

McBride, David J. ;

Humphray, Sean J. ;

Greenman, Chris D. ;

Varela, Ignacio ;

Lin, Meng-Lay ;

Ordonez, Gonzalo R. ;

Bignell, Graham R. ;

Ye, Kai ;

Alipaz, Julie ;

Bauer, Markus J. ;

Beare, David ;

Butler, Adam ;

Carter, Richard J. ;

Chen, Lina ;

Cox, Anthony J. ;

Edkins, Sarah ;

Kokko-Gonzales, Paula I. ;

Gormley, Niall A. ;

Grocock, Russell J. ;

Haudenschild, Christian D. ;

Hims, Matthew M. ;

James, Terena ;

Jia, Mingming ;

Kingsbury, Zoya ;

Leroy, Catherine ;

Marshall, John ;

Menzies, Andrew ;

Mudie, Laura J. ;

Ning, Zemin ;

Royce, Tom ;

Schulz-Trieglaff, Ole B. ;

Spiridou, Anastassia ;

Stebbings, Lucy A. ;

Szajkowski, Lukasz ;

Teague, Jon ;

Williamson, David ;

Chin, Lynda ;

Ross, Mark T. ;

Campbell, Peter J. ;

Bentley, David R. ;

Futreal, P. Andrew ;

Stratton, Michael R. .

NATURE, 2010, 463 (7278) :191-U73

[7]

Local dystrophin restoration with antisense oligonucleotide PRO051 [J].

van Deutekom, Judith C. ;

Janson, Anneke A. ;

Ginjaar, Ieke B. ;

Frankhuizen, Wendy S. ;

Aartsma-Rus, Annemieke ;

Bremmer-Bout, Mattie ;

den Dunnen, Johan T. ;

Koop, Klaas ;

van der Kooi, Anneke J. ;

Goemans, Nathalie M. ;

de Kimpe, Sjef J. ;

Ekhart, Peter F. ;

Venneker, Edna H. ;

Platenburg, Gerard J. ;

Verschuuren, Jan J. ;

van Ommen, Gert-Jan B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (26) :2677-2686

[8]

The genomic landscapes of human breast and colorectal cancers [J].

Wood, Laura D. ;

Parsons, D. Williams ;

Jones, Sian ;

Lin, Jimmy ;

Sjoblom, Tobias ;

Leary, Rebecca J. ;

Shen, Dong ;

Boca, Simina M. ;

Barber, Thomas ;

Ptak, Janine ;

Silliman, Natalie ;

Szabo, Steve ;

Dezso, Zoltan ;

Ustyanksky, Vadim ;

Nikolskaya, Tatiana ;

Nikolsky, Yuri ;

Karchin, Rachel ;

Wilson, Paul A. ;

Kaminker, Joshua S. ;

Zhang, Zemin ;

Croshaw, Randal ;

Willis, Joseph ;

Dawson, Dawn ;

Shipitsin, Michail ;

Willson, James K. V. ;

Sukumar, Saraswati ;

Polyak, Kornelia ;

Park, Ben Ho ;

Pethiyagoda, Charit L. ;

Pant, P. V. Krishna ;

Ballinger, Dennis G. ;

Sparks, Andrew B. ;

Hartigan, James ;

Smith, Douglas R. ;

Suh, Erick ;

Papadopoulos, Nickolas ;

Buckhaults, Phillip ;

Markowitz, Sanford D. ;

Parmigiani, Giovanni ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Vogelstein, Bert .

SCIENCE, 2007, 318 (5853) :1108-1113

[9]

ASF/SF2-Regulated CaMKIIδ alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle [J].

Xu, XD ;

Yang, DM ;

Ding, JH ;

Wang, W ;

Chu, PH ;

Dalton, ND ;

Wang, HY ;

Bermingham, JR ;

Ye, Z ;

Liu, F ;

Rosenfeld, MG ;

Manley, JL ;

Ross, J ;

Chen, J ;

Xiao, RP ;

Cheng, HP ;

Fu, XD .

CELL, 2005, 120 (01) :59-72

[10]

Frequent pathway mutations of splicing machinery in myelodysplasia [J].

Yoshida, Kenichi ;

Sanada, Masashi ;

Shiraishi, Yuichi ;

Nowak, Daniel ;

Nagata, Yasunobu ;

Yamamoto, Ryo ;

Sato, Yusuke ;

Sato-Otsubo, Aiko ;

Kon, Ayana ;

Nagasaki, Masao ;

Chalkidis, George ;

Suzuki, Yutaka ;

Shiosaka, Masashi ;

Kawahata, Ryoichiro ;

Yamaguchi, Tomoyuki ;

Otsu, Makoto ;

Obara, Naoshi ;

Sakata-Yanagimoto, Mamiko ;

Ishiyama, Ken ;

Mori, Hiraku ;

Nolte, Florian ;

Hofmann, Wolf-Karsten ;

Miyawaki, Shuichi ;

Sugano, Sumio ;

Haferlach, Claudia ;

Koeffler, H. Phillip ;

Shih, Lee-Yung ;

Haferlach, Torsten ;

Chiba, Shigeru ;

Nakauchi, Hiromitsu ;

Miyano, Satoru ;

Ogawa, Seishi .

NATURE, 2011, 478 (7367) :64-69

← 1 →