Tocilizumab-Conjugated Polymer Nanoparticles for NIR-II Photoacoustic-Imaging-Guided Therapy of Rheumatoid Arthritis

被引：156

作者：

Chen, Jingqin ^{[1
,3
]}

Qi, Ji ^{[4
]}

Chen, Chao ^{[5
]}

Chen, Jianhai ^{[2
,3
]}

Liu, Liangjian ^{[1
]}

Gao, Rongkang ^{[1
]}

Zhang, Tiantian ^{[6
]}

Song, Liang ^{[1
]}

Ding, Dan ^{[5
]}

Zhang, Peng ^{[2
]}

Liu, Chengbo ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol,Res Lab Biomed Opt & Mo, CAS Key Lab Hlth Informat,Shenzhen Key Lab Mol Im, Guangdong Prov Key Lab Biomed Opt Imaging Technol, Shenzhen 518055, Peoples R China

[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Engn Res Ctr Med Bioact Mat, Ctr Translat Med Res & Dev, Shenzhen 518055, Peoples R China

[3] Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Shenzhen 518055, Peoples R China

[4] Harvard Med Sch, Boston Childrens Hosp, Div Crit Care Med, Dept Anesthesiol,Lab Biomat & Drug Delivery, 300 Longwood Ave, Boston, MA 02115 USA

[5] Nankai Univ, Coll Life Sci, Minist Educ, Key Lab Bioact Mat,State Key Lab Med Chem Biol, 94 Weijin Rd, Tianjin 300071, Peoples R China

[6] Peoples Hosp Baoan Dist, Dept Rheumatol, Shenzhen 518128, Peoples R China

来源：

ADVANCED MATERIALS | 2020年 / 32卷 / 37期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

photoacoustic molecular imaging; polymer nanoparticles; rheumatoid arthritis; second near infrared window; tocilizumab; COLLAGEN-INDUCED ARTHRITIS; EARLY-DIAGNOSIS; INFLAMMATION; SURFACE; AGENT; MICE;

D O I：

10.1002/adma.202003399

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The progressive debilitating nature of rheumatoid arthritis (RA) combined with its unknown etiology and initial similarity to other inflammatory diseases makes early diagnosis a significant challenge. Early recognition and treatment of RA is essential for achieving effective therapeutic outcome. NIR-II photoacoustic (PA) molecular imaging (PMI) is emerging as a promising new strategy for effective diagnosis and treatment guidance of RA, owing to its high sensitivity and specificity at large penetration depth. Herein, an antirheumatic targeted drug tocilizumab (TCZ) is conjugated to polymer nanoparticles (PNPs) to develop the first NIR-II theranostic nanoplatform, named TCZ-PNPs, for PA-imaging-guided therapy of RA. The TCZ-PNPs are demonstrated to have strong NIR-II extinction coefficient, high photostability and excellent biocompatibility. NIR-II PMI results reveal the excellent targeting abilities of TCZ-PNPs for the effective noninvasive diagnosis of RA joint tissue with a high signal-to noise ratio (SNR) of 35.8 dB in 3D PA tomography images. Remarkably, one-month treatment and PA monitoring using TCZ-PNPs shows RA is significantly suppressed. In addition, the therapeutic evaluation of RA mice by NIR-II PMI is shown to be consistent with clinical micro-CT and histological analysis. The TCZ-PNPs-assisted NIR-II PMI provides a new strategy for RA theranostics, therapeutic monitoring and the beyond.

引用

页数：9

共 60 条

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