Predicting cognitive decline in healthy older adults

被引：53

作者：

De Jager, C

Blackwell, AD

Budge, MM

Sahakian, BJ

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Psychiat, Cambridge CB2 2QQ, England

[2] Univ Oxford, OPTIMA, Dept Pharmacol, Oxford, England

[3] Australian Natl Univ, Sch Med, Dept Geriatr Med, Canberra, ACT, Australia

来源：

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2005年 / 13卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1176/appi.ajgp.13.8.735

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.

引用

页码：735 / 740

页数：6

共 14 条

[1] Detecting dementia: Novel neuropsychological markers of preclinical Alzheimer's disease [J].