Intraflagellar transport: Keeping the motors coordinated

被引:15
作者
Cole, DG [1 ]
机构
[1] Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA
关键词
D O I
10.1016/j.cub.2005.09.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Intraflagellar transport is a conserved delivery system that services eukaryotic cilia and flagella. Recent work in the nematode Caenorhabditis elegans has identified proteins required for the functional coordination of intraflagellar transport motors and their cargoes.
引用
收藏
页码:R798 / R801
页数:4
相关论文
共 19 条
[1]   Loss of C-elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport [J].
Blacque, OE ;
Reardon, MJ ;
Li, CM ;
McCarthy, J ;
Mahjoub, MR ;
Ansley, SJ ;
Badano, LL ;
Mah, AK ;
Beales, PL ;
Davidson, WS ;
Johnsen, RC ;
Audeh, M ;
Plasterk, RHA ;
Baillie, DL ;
Katsanis, N ;
Quarmby, LM ;
Wicks, SR ;
Leroux, MR .
GENES & DEVELOPMENT, 2004, 18 (13) :1630-1642
[2]   The intraflagellar transport machinery of Chlamydomonas reinhardtii [J].
Cole, DG .
TRAFFIC, 2003, 4 (07) :435-442
[3]   Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT):: IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons [J].
Cole, DG ;
Diener, DR ;
Himelblau, AL ;
Beech, PL ;
Fuster, JC ;
Rosenbaum, JL .
JOURNAL OF CELL BIOLOGY, 1998, 141 (04) :993-1008
[4]   Cilia and disease [J].
Eley, L ;
Yates, LM ;
Goodship, JA .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (03) :308-314
[5]   A MOTILITY IN THE EUKARYOTIC FLAGELLUM UNRELATED TO FLAGELLAR BEATING [J].
KOZMINSKI, KG ;
JOHNSON, KA ;
FORSCHER, P ;
ROSENBAUM, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) :5519-5523
[6]   Protein prenyltransferases: Anchor size, pseudogenes and parasites [J].
Maurer-Stroh, S ;
Washietl, S ;
Eisenhaber, F .
BIOLOGICAL CHEMISTRY, 2003, 384 (07) :977-989
[7]   Establishing a connection between cilia and Bardet-Biedl Syndrome [J].
Mykytyn, K ;
Sheffield, VC .
TRENDS IN MOLECULAR MEDICINE, 2004, 10 (03) :106-109
[8]   Functional coordination of intraflagellar transport motors [J].
Ou, GS ;
Blacque, OE ;
Snow, JJ ;
Leroux, MR ;
Scholey, JM .
NATURE, 2005, 436 (7050) :583-587
[9]   The PKD protein qilin undergoes intraflagellar transport [J].
Ou, GS ;
Qin, HM ;
Rosenbaum, JL ;
Scholey, JM .
CURRENT BIOLOGY, 2005, 15 (11) :R410-R411
[10]   Proteomic analysis of a eukaryotic cilium [J].
Pazour, GJ ;
Agrin, N ;
Leszyk, J ;
Witman, GB .
JOURNAL OF CELL BIOLOGY, 2005, 170 (01) :103-113