A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents

被引：44

作者：

Agarwal, A

Srivastava, K

Puri, SK

Sinha, S

Chauhan, PMS ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

[3] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 23期

关键词：

malaria; dihydrofolate reductase; solid phase synthesis; combinatorial chemistry;

D O I：

10.1016/j.bmcl.2005.08.053

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activity. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2 mu g/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 12.5 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5218 / 5221

页数：4

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