Motor system excitability in patients with restless legs syndrome

被引：123

作者：

Tergau, F ^{[1
]}

Wischer, S ^{[1
]}

Paulus, W ^{[1
]}

机构：

[1] Univ Gottingen, Dept Clin Neurophysiol, D-37075 Gottingen, Germany

来源：

NEUROLOGY | 1999年 / 52卷 / 05期

关键词：

D O I：

10.1212/WNL.52.5.1060

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In 18 patients with idiopathic restless legs syndrome (RLS), intracortical inhibition by paired transcranial magnetic stimulation (TMS) was significantly reduced for both foot and hand muscles, suggesting that the entire motor cortex is disinhibited in RLS. Decreased intracortical facilitation in the foot muscle but not in the hand muscle may be due to subliminal activation of the symptomatic lower limbs. Motor excitability measurements of single TMS were not altered. These results support a subcortical origin of RLS.

引用

页码：1060 / 1063

页数：4

共 10 条

[1] Blink reflex excitability is abnormal in patients with periodic leg movements in sleep [J].

Briellmann, RS ;

Rosler, KM ;

Hess, CW .

MOVEMENT DISORDERS, 1996, 11 (06) :710-714

[2] Cerebral generators involved in the pathogenesis of the restless legs syndrome [J].

Bucher, SF ;

Seelos, KC ;

Oertel, WH ;

Reiser, M ;

Trenkwalder, C .

ANNALS OF NEUROLOGY, 1997, 41 (05) :639-645

[3] Reflex studies and MRI in the restless legs syndrome [J].

Bucher, SF ;

Trenkwalder, C ;

Oertel, WH .

ACTA NEUROLOGICA SCANDINAVICA, 1996, 94 (02) :145-150

[4] Ipsilateral cortico-cortical inhibition of the motor cortex in various neurological disorders [J].

Hanajima, R ;

Ugawa, Y ;

Terao, Y ;

Ogata, K ;

Kanazawa, I .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1996, 140 (1-2) :109-116

[5] CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX [J].

KUJIRAI, T ;

CARAMIA, MD ;

ROTHWELL, JC ;

DAY, BL ;

THOMPSON, PD ;

FERBERT, A ;

WROE, S ;

ASSELMAN, P ;

MARSDEN, CD .

JOURNAL OF PHYSIOLOGY-LONDON, 1993, 471 :501-519

[6] THE EFFECT OF VOLUNTARY CONTRACTION ON CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX [J].

RIDDING, MC ;

TAYLOR, JL ;

ROTHWELL, JC .

JOURNAL OF PHYSIOLOGY-LONDON, 1995, 487 (02) :541-548

[7] Periodic limb movements and restless legs syndrome [J].

Trenkwalder, C ;

Walters, AS ;

Hening, W .

NEUROLOGIC CLINICS, 1996, 14 (03) :629-&

[8] TOWARD A BETTER DEFINITION OF THE RESTLESS LEGS SYNDROME [J].

WALTERS, AS .

MOVEMENT DISORDERS, 1995, 10 (05) :634-642

[9] Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs [J].

Ziemann, U ;

Tergau, F ;

Bruns, D ;

Baudewig, J ;

Paulus, W .

ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1997, 105 (06) :430-437

[10] Inhibition of human motor cortex by ethanol - A transcranial magnetic stimulation study [J].

Ziemann, U ;

Lonnecker, S ;

Paulus, W .

BRAIN, 1995, 118 :1437-1446

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