Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress

被引：175

作者：

Bahrami, Afsane ^{[1
,2
]}

Khazaei, Majid ^{[3
,4
]}

Hasanzadeh, Malihe ^{[5
]}

ShahidSales, Soodabeh ^{[6
]}

Joudi Mashhad, Mona ^{[6
]}

Farazestanian, Marjaneh ^{[5
]}

Sadeghnia, Hamid Reza ^{[1
]}

Rezayi, Majid ^{[1
]}

Maftouh, Mina ^{[2
]}

Hassanian, Seyed Mahdi ^{[2
,7
]}

Avan, Amir ^{[2
,6
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran

[2] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Neurogen Inflammatory Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Med, Dept Physiol, Mashhad, Iran

[5] Mashhad Univ Med Sci, Dept Gynecol Oncol, Woman Hlth Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Sch Med, Canc Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Sch Med, Dept Med Biochem, Mashhad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2018年 / 119卷 / 03期

关键词：

PI3K/AKT/mTOR PATHWAY; COLORECTAL CANCER; THERAPEUTIC TARGET; CELL SURVIVAL; PHASE-II; SELECTIVE INHIBITOR; ANTITUMOR-ACTIVITY; PIK3CA MUTATIONS; MTOR INHIBITORS; TUMOR-GROWTH; EVEROLIMUS; TRIAL; COMBINATION; OXALIPLATIN;

D O I：

10.1002/jcb.25950

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown to be related with cellular transformation, tumor progression, cell survival, and drug resistance. There is growing body of data evaluating the value of PI3K/AKT/mTOR inhibitors in CRC (e.g., BEZ235, NVP-BEZ235, OSI-027, everolimus, MK-2206, KRX-0401, BYL719, and BKM120). This report summarizes the current knowledge about PI3K/AKT pathway and its cross talk with ERK/MAPK and mTOR pathways with particular emphasis on the value of targeting this pathway as a potential therapeutic target in treatment of colorectal cancer. (c) 2017 Wiley Periodicals, Inc.

引用

页码：2460 / 2469

页数：10

共 52 条

[1]

Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population [J].