Energy dispersive X-ray diffraction study of phase development during hardening of calcium phosphate bone cements with addition of chitosan

被引：25

作者：

Rau, J. V. ^{[2
]}

Generosi, A. ^{[3
]}

Smirnov, V. V. ^{[1
]}

Ferro, D. ^{[2
]}

Albertini, V. Rossi ^{[3
]}

Barinov, S. M. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Phys Chem Ceram, Moscow 119361, Russia

[2] CNR, Ist Studio Mat Nanostrutturati, I-0185 Rome, Italy

[3] CNR, Ist Struttura Mat, I-00133 Rome, Italy

来源：

ACTA BIOMATERIALIA | 2008年 / 4卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

calcium phosphate bone cements; chitosan; phase transformations; X-ray diffraction;

D O I：

10.1016/j.actbio.2008.01.006

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

The aim of this work was to study the phase transformation during the setting reaction of two calcium phosphate bone cements based on either alpha tricalcium phosphate (alpha-TCP) or tetracalciurn phosphate (TetCP) initial solid phase, and a magnesium carbonate-phosphoric acid solution as the hardening liquid. Low molecular weight (38.2 kDa) chitosan was used to retard the cement's setting reaction. To follow the kinetics of the phase development, an energy dispersive X-ray diffraction technique was applied. This technique allowed the collection of diffraction patterns from the cement pastes in situ starting from 1 min of the setting process. In the case of the TetCP-based cement, the appearance and evolution of an intermediate phase was detected. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1089 / 1094

页数：6

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