Cell cycle regulation during early mouse embryogenesis

被引:35
作者
Artus, Jerome [1 ]
Cohen-Tannoudji, Michel [1 ]
机构
[1] Inst Pasteur, Unite Genet Fonct Souris, CNRS, URA 2578, F-75724 Paris 05, France
关键词
cell cycle; checkpoints; early mouse development; endoreplication; gene targeting; Ovum mutant candidate gene 1; peri-implantation lethality;
D O I
10.1016/j.mce.2007.11.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Elaboration of a multicellular organism requires highly efficient coordination between proliferation and developmental processes. Accordingly, the embryonic cell cycle exhibits a high degree of plasticity; however, the mechanisms underlying its regulation in vivo remain largely unknown. The purpose of this review is to summarize the data on cell cycle regulation during the early mouse embryonic development, a period characterized by major variations in cell cycle parameters which correlate with important developmental transitions. In particular, we analyse the contribution of mutant mice to the study of in vivo cell cycle regulation during early development and discuss possible contributions of cell cycle regulators to developmental programs. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:78 / 86
页数:9
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