Liver injury in COVID-19: The current evidence

被引：173

作者：

Alqahtani, Saleh A. ^{[1
,2
]}

Schattenberg, Joern M. ^{[3
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Liver Transplantat Unit, Riyadh, Saudi Arabia

[2] Johns Hopkins Univ, Div Gastroenterol & Hepatol, Baltimore, MD USA

[3] Univ Med Ctr, Dept Med 1, Metab Liver Res Program, Mainz, Germany

来源：

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL | 2020年 / 8卷 / 05期

关键词：

SARS-CoV2; COVID-19; liver injury; liver function test; cholangiocytes; lymphopenia; cytokine storm; PNEUMONIA; WUHAN;

D O I：

10.1177/2050640620924157

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. Recent studies proposed several theories on potential mechanisms of liver injury in these patients. This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.

引用

页码：509 / 519

页数：11

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