Protective role of DL-α-lipoic acid against mercury-induced neural lipid peroxidation

被引：34

作者：

Anuradha, B ^{[1
]}

Varalakshmi, P ^{[1
]}

机构：

[1] Univ Madras, Dr AL Mudaliar Post Grad Inst Basic Med Sci, Dept Biochem Med, Madras 600113, Tamil Nadu, India

来源：

PHARMACOLOGICAL RESEARCH | 1999年 / 39卷 / 01期

关键词：

mercuric chloride; DL-alpha-lipoic acid; lipid peroxidation; enzymic and non-enzymic antioxidants;

D O I：

10.1006/phrs.1998.0408

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Experimental neurotoxicity in rat models was induced by an intramuscular injection of mercuric chloride. DL-alpha-lipoic acid was administered as an antidote in three protocols of experimental design. Two protocols of short-term exposure of mercury was designed, one with prophylactic therapy and the other with curative therapy of lipoic acid. The third protocol was with prophylactic therapy of lipoic acid on long-term exposure of mercury. Enhanced lipid peroxidation, depleted non-enzymic and perturbed enzymic antioxidant status were observed in cerebral cortex, cerebellum and sciatic nerves of the toxic groups. The ameliorating effect of lipoic acid and its therapeutic efficacy during various modes of therapy, on the antioxidant status was established in the nervous tissues. (C) 1999 The Italian Pharmacological Society.

引用

页码：67 / 80

页数：14

共 27 条

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PROTECTION AGAINST CISPLATIN TOXICITY BY ADMINISTRATION OF GLUTATHIONE ESTER [J].