p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells

被引：240

作者：

Narayanan, BA

Geoffroy, O

Willingham, MC

Re, GG

Nixon, DW

机构：

[1] Med Univ S Carolina, Hollings Canc Ctr, Canc Prevent Program, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA

来源：

CANCER LETTERS | 1999年 / 136卷 / 02期

关键词：

ellagic acid; ellagitannins; apoptosis; CaSki cells;

D O I：

10.1016/S0304-3835(98)00323-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogen-induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G1 arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：215 / 221

页数：7

共 19 条

[1] The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes [J].