Neuronal expression of fractalkine in the presence and absence of inflammation

被引：89

作者：

Schwaeble, WJ

Stover, CM

Schall, TJ

Dairaghi, DJ

Trinder, PKE

Linington, C

Iglesias, A

Schubart, A

Lynch, NJ

Weihe, E

Schäfer, MKH

机构：

[1] Univ Leicester, Dept Microbiol & Immunol, Leicester LE1 9HN, Leics, England

[2] Univ Marburg, Dept Anat & Cell Biol, D-35033 Marburg, Germany

[3] ChemoCentryx, San Carlos, CA 94306 USA

[4] Max Planck Inst Psychiat, D-82152 Martinsried, Germany

来源：

FEBS LETTERS | 1998年 / 439卷 / 03期

基金：

美国国家卫生研究院;

关键词：

fractalkine; experimentally induced allergic encephalomyelitis; inflammation; neuronal expression;

D O I：

10.1016/S0014-5793(98)01384-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fractalkine is the only as get known member of a novel class of chemokines, Besides its novel Cys-X-X-X-Cys motif, fractalkine exhibits features which have not been described for any other member of the chemokine family, including its unusual size (397 amino acids human, 395 mouse) and the possession of a transmembrane anchor, from which a soluble form may be released by extracellular cleavage. This report demonstrates the abundant mRNA and fractalkine protein expression in neuronal cells. The neuronal expression of fractalkine mRNA is unaffected by experimentally induced inflammation of central nervous tissue. (C) 1998 Federation of European Biochemical Societies.

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收藏

页码：203 / 207

页数：5

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