Dendritic cells signal T cells in the absence of exogenous antigen

被引：71

作者：

Kondo, T

Cortese, I

Markovic-Plese, S

Wandinger, KP

Carter, C

Brown, M

Leitman, S

Martin, R ^{[1
]}

机构：

[1] NINCDS, Cellular Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA

[2] NIH, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA

[3] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 10期

关键词：

D O I：

10.1038/ni711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interactions with self-major histocompatibility complex molecules on dendritic cells (DCs) are important for the survival of mature CD4(+)T cells. We have followed the DC-mediated signal from the T cell surface to the nucleus and identified a pattern of activation that correlates with increased in vitro survival. This response is induced exclusively by DCs and is likely associated with a modulation of the T cell activation threshold. We have also found that DC-mediated activation results in antigen-independent cytokine gene expression, which points to a new role for DCs in shaping the cytokine milieu. Such antigen-independent activation of T cells may play a role in protective immunity, but may also induce and perpetuate autoimmune states such as multiple sclerosis.

引用

页码：932 / 938

页数：7

共 39 条

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