Pharmacokinetic Comparisons of Albiflorin and Paeoniflorin after Oral Administration of Shaoyao-Gancao-Tang and Single Herb Paeony Decoction to Rats

被引：50

作者：

Gan, Pingping ^{[1
]}

Zhong, Meizuo ^{[1
]}

Huang, Xi ^{[2
]}

Sun, Ming ^{[3
]}

Wang, Yang ^{[2
]}

Xiao, Yanying ^{[4
]}

Zeng, Chang ^{[5
]}

Yuan, Qiongjing ^{[6
]}

Liu, Zhaoqian ^{[7
]}

Zhou, Honghao ^{[7
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Inst Integrated Tradit Med & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Hunan, Peoples R China

[4] Cent S Univ, Xiangya Hosp 2, Dept Anesthesiol, Changsha 410008, Hunan, Peoples R China

[5] Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China

[6] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China

[7] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410008, Hunan, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 03期

关键词：

Shaoyao-Gancao-Tang; albiflorin; paeoniflorin; pharmacokinetic; UPLC; RADIX PAEONIAE ALBA; GLYCYRRHIZA-URALENSIS; SCUTELLARIAE EXTRACT; IN-VIVO; CONSTITUENTS; ROOT; LACTIFLORA; MEDICINES; BAICALIN; RECEPTOR;

D O I：

10.1055/s-0031-1280366

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Shaoyao-Gancao-Tang (SGT) is a traditional Chinese prescription containing Radix Paeoniae alba and Radix Glycyrrhizae and is commonly used to relieve pains. Albiflorin and paeoniflorin are the main effective compounds of Radix Paeoniae alba, and the pharmacokinetic differences of the two compounds in rats after oral administration of SGT and single herb Paeony decoction were studied. At different time points (5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240, 360, and 540 min) after administration, plasma concentrations of albiflorin and paeoniflorin were determined using a simple and reliable UPLC method, and main pharmacokinetic parameters were evaluated. It was found that there were significant differences (p < 0.05 or p < 0.01) between the two groups. The results indicated that some components in the other ingredient herb of SGT (Radix Glycyrrhizae) had a pharmacokinetic interaction with albiflorin and paeoniflorin and hence reduced their systematic exposure level.

引用

页码：237 / 243

页数：7

共 33 条

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