The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study

被引：14

作者：

Protheroe, R. E. ^{[1
]}

Kirkland, K. E. ^{[2
]}

Pearce, R. M. ^{[3
]}

Kaminaris, K. ^{[4
]}

Bloor, A. ^{[5
]}

Potter, M. N. ^{[6
]}

Nagra, S. ^{[7
]}

Gilleece, M. H. ^{[8
]}

McQuaker, I. G. ^{[9
]}

Jackson, G. ^{[10
]}

Cook, G. ^{[8
]}

Marks, D. I. ^{[1
]}

机构：

[1] Univ Hosp Bristol, Bristol Adult Bone Marrow Transplant Unit, Bristol BS2 8BJ, Avon, England

[2] British Soc Blood & Marrow Transplantat, Data Registry, London, England

[3] British Soc Blood & Marrow Transplantat, Clin Trials Comm Statistician, London, England

[4] Univ Coll Hosp, London, England

[5] Christie Hosp, Dept Haematol, Manchester, Lancs, England

[6] Royal Marsden Hosp, Bone Marrow Transplant Unit, London SW3 6JJ, England

[7] Univ Hosp, Ctr Clin Haematol, Birmingham, W Midlands, England

[8] St James Hosp, Leeds LS9 7TF, W Yorkshire, England

[9] Glasgow Royal Infirm, Bone Marrow Transplant Unit, Glasgow G4 0SF, Lanark, Scotland

[10] Royal Victoria Infirm, Dept Haematol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

来源：

BONE MARROW TRANSPLANTATION | 2012年 / 47卷 / 01期

关键词：

H1N1; influenza; Allo-SCT; immunocompromised; pneumonia; risk factors; RESPIRATORY VIRUS-INFECTIONS; STEM-CELL TRANSPLANTATION; IMMUNOCOMPROMISED PATIENTS; A(H1N1) INFECTION; EXPERIENCE; RECIPIENTS; MORTALITY;

D O I：

10.1038/bmt.2011.12

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk. Bone Marrow Transplantation (2012) 47, 88-94; doi: 10.1038/bmt.2011.12; published online 28 February 2011

引用

页码：88 / 94

页数：7

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