Stabilization of DNA triplexes by dangling aromatic residues

被引：8

作者：

Kubota, M ^{[1
]}

Ono, A ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Dept Chem, Grad Sch Sci, Tokyo 1920397, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 06期

关键词：

D O I：

10.1016/j.tetlet.2003.11.144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel nucleoside analogues containing 2'-deoxyinosine and aromatic rings, which are connected by short linker groups, were synthesized and incorporated into oligodeoxyribonucleotides (ODNs). ODNs containing the nucleoside analogues formed stable duplexes and triplexes with target nucleic acids. The stacking interaction between base residues in the nucleoside analogues appears to be a major cause of stabilization. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1187 / 1190

页数：4

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