Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)

被引：127

作者：

Bouhlal, Rhimou ^{[1
,2
]}

Haslin, Camille ^{[3
]}

Chermann, Jean-Claude ^{[3
]}

Colliec-Jouault, Sylvia ^{[4
]}

Sinquin, Corinne ^{[4
]}

Simon, Gaelle ^{[5
]}

Cerantola, Stephane ^{[5
]}

Riadi, Hassane ^{[2
]}

Bourgougnon, Nathalie ^{[1
]}

机构：

[1] Univ Bretagne Sud Vannes, UEB, Ctr Rech Yves Coppens, LBCM, Vannes, France

[2] Univ Abdelmalek Essaadi, Fac Sci, Lab Diversite & Conservat Syst Biol LDICOSYB, Tetouan 93003, Morocco

[3] Ctr Vie Agora, URRMA R&D, F-13781 Zi Des Paluds, Aubagne, France

[4] IFREMER, Lab Biotechnol & Mol Marines, F-44311 Nantes, France

[5] Univ Bretagne Occidentale, Univ Europeenne Bretagne, Serv Commun Resonance Magnet Nucl, UFR Sci & Tech, F-29238 Brest 3, France

来源：

MARINE DRUGS | 2011年 / 9卷 / 07期

关键词：

Herpes simplex virus; human immunodeficiency virus; antiviral activity; sulfated polysaccharide; S; coronopifolius; B; thuyoides; chemical composition; SCHIZYMENIA-DUBYI RHODOPHYTA; HERPES-SIMPLEX-VIRUS; CELL-WALL POLYSACCHARIDES; RED ALGA; SEAWEED POLYSACCHARIDES; ANTIHERPETIC ACTIVITY; STRUCTURAL-ANALYSIS; TETRASPORIC STAGES; GALACTAN SULFATE; AGAR;

D O I：

10.3390/md9071187

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 mu g/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC50 of 4.1 and 17.2 mu g/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and potential virucidal effect. The polysaccharides from S. coronopifolius (PSC) and B. thuyoides (PBT) were composed of galactose, 3,6-anhydrogalactose, uronics acids, sulfate in ratios of 33.1, 11.0, 7.7 and 24.0% (w/w) and 25.4, 16.0, 3.2, 7.6% (w/w), respectively.

引用

页码：1187 / 1209

页数：23

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