No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET

被引：60

作者：

Trichard, C

Paillère-Martinot, ML

Attar-Levy, D

Blin, J

Feline, A

Martinot, JL

机构：

[1] CEA, Serv Hosp Frederic Joliot, INSERM U334, DRM,DSV, F-91406 Orsay, France

[2] Ctr Hosp Gen, Gonesse, France

[3] Hop La Pitie Salpetriere, Paris, France

[4] SHU Hop Ste Anne, Paris, France

[5] Hop Bicetre, Le Kremlin Bicetre, France

[6] Hop A Chenevier, Creteil, France

来源：

SCHIZOPHRENIA RESEARCH | 1998年 / 31卷 / 01期

关键词：

schizophrenia; 5-HT2A receptor; PET;

D O I：

10.1016/S0920-9964(98)00014-0

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

To investigate putative abnormalities of cortical 5-HT2A receptor density in schizophrenia, we used positron emission tomography and [F-18]setoperone, a high-affinity 5-HT2A receptor radioligand, in 14 neuroleptic-free or -naive schizophrenic patients and in 15 normal controls. No significant difference between the groups was observed in the whole or regional cortical binding potential of [F-18]setoperone, indicating an absence of major 5-HT2A receptor cortical density abnormalities in schizophrenics. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：13 / 17

页数：5

相关论文

共 24 条

[1] SEROTONIN-2 (5-HT2) RECEPTOR-BINDING IN THE FRONTAL-CORTEX OF SCHIZOPHRENIC-PATIENTS [J].

ARORA, RC ;

MELTZER, HY .

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1991, 85 (01) :19-29

[2]

BENNETT JP, 1979, ARCH GEN PSYCHIAT, V36, P927

[3] A METHOD FOR THE INVIVO INVESTIGATION OF THE SEROTONERGIC 5-HT2 RECEPTORS IN THE HUMAN CEREBRAL-CORTEX USING POSITRON EMISSION TOMOGRAPHY AND F-18 LABELED SETOPERONE [J].

BLIN, J ;

SETTE, G ;

FIORELLI, M ;

BLETRY, O ;

ELGHOZI, JL ;

CROUZEL, C ;

BARON, JC .

JOURNAL OF NEUROCHEMISTRY, 1990, 54 (05) :1744-1754

[4] LABELING OF A SEROTONINERGIC LIGAND WITH F-18 - [F-18] SETOPERONE [J].

CROUZEL, C ;

VENET, M ;

IRIE, T ;

SANZ, G ;

BOULLAIS, C .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1988, 25 (04) :403-414

[5]

Goyer PF, 1996, J NUCL MED, V37, P1122

[6] SOME ANTICONVULSANT DRUGS ALTER MONOAMINE-MEDIATED BEHAVIOR IN MICE IN WAYS SIMILAR TO ELECTROCONVULSIVE SHOCK - IMPLICATIONS FOR ANTIDEPRESSANT THERAPY [J].

GREEN, AR ;

JOHNSON, P ;

MOUNTFORD, JA ;

NIMGAONKAR, VL .

BRITISH JOURNAL OF PHARMACOLOGY, 1985, 84 (02) :337-346

[7] AUTORADIOGRAPHIC ANALYSIS OF AGE-DEPENDENT CHANGES IN SEROTONIN 5-HT2 RECEPTORS OF THE HUMAN BRAIN POSTMORTEM [J].

GROSSISSEROFF, R ;

SALAMA, D ;

ISRAELI, M ;

BIEGON, A .

BRAIN RESEARCH, 1990, 519 (1-2) :223-227

[8] SEROTONIN UPTAKE SITES AND SEROTONIN RECEPTORS ARE ALTERED IN THE LIMBIC SYSTEM OF SCHIZOPHRENICS [J].

JOYCE, JN ;

SHANE, A ;

LEXOW, N ;

WINOKUR, A ;

CASANOVA, MF ;

KLEINMAN, JE .

NEUROPSYCHOPHARMACOLOGY, 1993, 8 (04) :315-336

[9]

LARUELLE M, 1993, ARCH GEN PSYCHIAT, V50, P810

[10] DRUG-RECEPTOR DISSOCIATION TIME, NEW TOOL FOR DRUG RESEARCH - RECEPTOR-BINDING AFFINITY AND DRUG-RECEPTOR DISSOCIATION PROFILES OF SEROTONIN-S2, DOPAMINE-D2, HISTAMINE-H-1 ANTAGONISTS, AND OPIATES [J].

LEYSEN, JE ;

GOMMEREN, W .

DRUG DEVELOPMENT RESEARCH, 1986, 8 (1-4) :119-131