Estrogen-Related Receptors and the control of bone cell fate

被引：17

作者：

Carnesecchi, Julie ^{[1
,2
]}

Vanacker, Jean-Marc ^{[1
]}

机构：

[1] Univ Lyon 1, Ecole Normale Super Lyon, Inst Genom Fonct Lyon, CNRS UMR5242, Lyon, France

[2] Heidelberg Univ, Dept Dev Biol, Ctr Organismal Studies, Bergheimer Str 58, D-69115 Heidelberg, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2016年 / 432卷 / 0C期

关键词：

Mesenchymal cells; Estrogen-Related Receptors; Bone cells; Bone loss; ALPHA ERR-ALPHA; INDEPENDENT TRANSCRIPTIONAL ACTIVATION; BREAST-CANCER CELLS; PHOSPHORYLATION-DEPENDENT SUMOYLATION; ORPHAN NUCLEAR RECEPTORS; FORMATION IN-VITRO; OSTEOBLAST DIFFERENTIATION; OSTEOPONTIN PROMOTER; THERAPEUTIC TARGET; BISPHENOL-A;

D O I：

10.1016/j.mce.2015.07.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Bone loss is naturally occurring in aging males and females and exacerbated in the latter after menopause, altogether leading to cumulative skeleton fragility and increased fracture risk. Two types of therapeutic strategies can be envisioned to counteract age- or menopause-associated bone loss, aiming at either reducing bone resorption exerted by osteoclasts or, alternatively, promoting bone formation by osteoblasts. We here summarize data suggesting that inhibition of the Estrogen-Related Receptors alpha and/or gamma could promote bone formation and compensate for bone loss induced by ageing or estrogen deficiency. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：47 / 53

页数：7

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