Combinatorial approach to the development of fluorescent sensors for nanomolar aqueous copper

被引：71

作者：

Singh, A ^{[1
]}

Yao, QW ^{[1
]}

Tong, L ^{[1
]}

Still, WC ^{[1
]}

Sames, D ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

关键词：

chemosensors; fluorescence; copper ion; combinatorial chemistry;

D O I：

10.1016/S0040-4039(00)01714-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New fluorescent sensors for aqueous copper ions were developed via screening of metal ligand libraries. Identified ionophores were linked to a dansyl fluorophore reporter, affording copper ion sensors based on fluorescence quenching. Simple chemical. modification of identified ionophores generated sensors responsive to a broad range of copper ion concentrations (10 nM-35 muM). (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：9601 / 9605

页数：5

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