EST analyses predict the existence of a population of chimeric microRNA precursor-mRNA transcripts expressed in normal human and mouse tissues

被引：69

作者：

Smalheiser, NR ^{[1
]}

机构：

[1] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

来源：

GENOME BIOLOGY | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1186/gb-2003-4-7-403

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A significant population of expressed sequence tags (ESTs) encodes chimeric transcripts containing microRNA (miRNA) precursor sequences as well as pieces of adjacent mRNAs in sense orientation. These chimeric transcripts may potentially be involved in miRNA biosynthesis, and/or affect expression of adjacent mammalian mRNAs.

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