Hereditary neuroendocrine tumors of the gastroenteropancreatic system

被引：76

作者：

Anlauf, Martin

Garbrecht, Nele

Bauersfeld, Juliane

Schmitt, Anja

Henopp, Tobias

Komminoth, Paul

Heitz, Philipp U.

Perren, Aurel

Kloeppel, Guenter

机构：

[1] Univ Kiel, Dept Pathol, D-24105 Kiel, Germany

[2] Univ Zurich Hosp, Dept Pathol, CH-8091 Zurich, Switzerland

[3] Triemli Spital, Inst Pathol, Zurich, Switzerland

[4] Tech Univ Munich, Dept Pathol, D-8000 Munich, Germany

来源：

VIRCHOWS ARCHIV | 2007年 / 451卷

关键词：

neuroendocrine tumors; pancreas; gut; hereditary syndromes; multiple endocrine neoplasia type 1; neurofibromatosis; tuberous sclerosis complex; von Hippel-Lindau disease; gastrinoma; insulinoma; ENDOCRINE NEOPLASIA TYPE-1; HIPPEL-LINDAU-DISEASE; TUBEROUS SCLEROSIS COMPLEX; ISLET CELL TUMORS; CARCINOID-TUMORS; SUPPRESSOR GENE; MUTATIONAL ANALYSIS; DUODENAL SOMATOSTATINOMA; CONSENSUS CONFERENCE; FAMILIAL OCCURRENCE;

D O I：

10.1007/s00428-007-0450-3

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Approximately 5-10% of neuroendocrine tumors (NETs) of the gastroenteropancreatic system (GEP) have a hereditary background. The known inherited syndromes include multiple endocrine neoplasia type 1, neurofibromatosis type 1, von Hippel-Lindau disease, and the tuberous sclerosis complex. This review discusses for each of these syndromes the: (1) involved genes and specific types of mutations, (2) disease prevalence and penetrance, (3) affected neuroendocrine tissues and related clinical syndromes, (4) special morphological features of NETs and their putative precursor lesions. In addition, GEP-NETs clustering in individual families or associated with other malignancies without known genetic background are discussed.

引用

页码：S29 / S38

页数：10

共 92 条

[1] Hereditary pancreatic endocrine tumours [J].

Alexakis, N ;

Connor, S ;

Ghaneh, P ;

Lombard, M ;

Smart, HL ;

Evans, J ;

Hughes, M ;

Garvey, CJ ;

Vora, J ;

Vinjamuri, S ;

Sutton, R ;

Neoptolemos, JP .

PANCREATOLOGY, 2004, 4 (05) :417-433

[2] A FAMILIAL INSTANCE OF APPENDICEAL CARCINOID [J].

ANDERSON, RE .

AMERICAN JOURNAL OF SURGERY, 1966, 111 (05) :738-&

[3] Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas [J].

Anlauf, M ;

Perren, A ;

Meyer, CL ;

Schmid, S ;

Saremaslani, P ;

Kruse, ML ;

Weihe, E ;

Komminoth, P ;

Heitz, PU ;

Klöppel, G .

GASTROENTEROLOGY, 2005, 128 (05) :1187-1198

[4] Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions [J].

Anlauf, M. ;

Perren, A. ;

Henopp, T. ;

Rudolph, T. ;

Garbrecht, N. ;

Schmitt, A. ;

Raffel, A. ;

Gimm, O. ;

Weihe, E. ;

Knoefel, W. T. ;

Dralle, H. ;

Heitz, Ph U. ;

Komminoth, P. ;

Kloeppel, G. .

GUT, 2007, 56 (05) :637-644

[5] Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome [J].

Anlauf, M ;

Schlenger, R ;

Perren, A ;

Bauersfeld, J ;

Koch, CA ;

Dralle, H ;

Raffel, A ;

Knoefel, WT ;

Weihe, E ;

Ruszniewski, P ;

Couvelard, A ;

Komminoth, P ;

Heitz, PU ;

Klöppel, G .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (05) :560-574

[6] Sporadic versus hereditary gastrinomas of the duodenum and pancreas:: Distinct clinico-pathological and epidemiological features [J].

Anlauf, Martin ;

Garbrecht, Nele ;

Henopp, Tobias ;

Schmitt, Anja ;

Schlenger, Regina ;

Raffel, Andreas ;

Krausch, Markus ;

Gimm, Oliver ;

Eisenberger, Claus F. ;

Knoefel, Wolfram T. ;

Dralle, Henning ;

Komminoth, Paul ;

Heitz, Philipp U. ;

Perren, Aurel ;

Kloeppel, Guenter .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (34) :5440-5446

[7]

[Anonymous], WHO CLASSIFICATION T

[8]

[Anonymous], WHO CLASSIFICATION T

[9]

Babovic-Vuksanovic D, 1999, CANCER EPIDEM BIOMAR, V8, P715

[10] Characterization of mutations in patients with multiple endocrine neoplasia type 1 [J].

Bassett, JHD ;

Forbes, SA ;

Pannett, AAJ ;

Lloyd, SE ;

Christie, PT ;

Wooding, C ;

Edwards, CR ;

Monson, JP ;

Sampson, J ;

Wass, JAH ;

Harding, B ;

Besser, GM ;

Wheeler, MH ;

Thakker, RV .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (02) :232-244

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