Subpopulations of cortical GABAergic interneurons differ by their expression of D1 and D2 dopamine receptor subtypes

被引：90

作者：

LeMoine, C

Gaspar, P

机构：

[1] Univ Bordeaux 2, Lab Histol Embryol, CNRS, UMR 5541, F-33076 Bordeaux, France

[2] Hop La Pitie Salpetriere, INSERM, U106, F-75651 Paris 13, France

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 58卷 / 1-2期

关键词：

dopamine receptor; gene expression; cortical interneuron; parvalbumin; calbindin;

D O I：

10.1016/S0169-328X(98)00118-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

D1 and D2 receptors have been described in different populations of efferent pyramidal neurons of the rat frontal cortex. Combined in situ hybridization and immunocytochemistry show here that these two subtypes are expressed in cortical GABAergic interneurons, with D1 and D2 mainly found in a subpopulation containing parvalbumin, whereas only 10% of the calbindin neurons express D1 receptors. These data indicate that various DA agonists may influence inhibitory circuits by distinct dopamine receptor subtypes. (C) 1998 Elsevier Science B.V. All rights reserved.

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收藏

页码：231 / 236

页数：6

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