Regulation of ErbB receptor signalling in cancer cells by microRNA

被引：20

作者：

Barker, Andrew

Giles, Keith M.

Epis, Michael R.

Zhang, Priscilla M.

Kalinowski, Felicity

Leedman, Peter J. ^{[1
]}

机构：

[1] Univ Western Australia, Lab Canc Med, Med Res Ctr, Westem Australian Inst Med Res, Perth, WA 6000, Australia

来源：

CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 06期

基金：

英国医学研究理事会;

关键词：

GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; LUNG-CANCER; EXPRESSION; MIR-21; GENE; SUPPRESSES; RESISTANCE; PATHWAY; FAMILY;

D O I：

10.1016/j.coph.2010.08.011

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Recent years have seen a massive expansion in our understanding of the biology of microRNAs (miRNAs) in cancer, through the identification of miRNAs with aberrant expression in specific cancers and the functional validation of their critical target molecules and cellular effects In parallel, targeted therapeutic agents to block signalling pathways critical to tumour growth and progression have been developed but have yielded disappointing clinical results The discovery of miRNAs that regulate ErbB signalling in cancer cells brings new hope that in the future these oncogenic pathways can be more effectively inhibited to improve patient outcomes

引用

页码：655 / 661

页数：7

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