An essential role of Bmp4 in the atrioventricular septation of the mouse heart

被引：283

作者：

Jiao, K

Kulessa, H

Tompkins, K

Zhou, YN

Batts, L

Baldwin, HS

Hogan, BLM

机构：

[1] Vanderbilt Univ, Med Ctr, Howard Hughes Med Inst, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Cardiol, Nashville, TN 37232 USA

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 19期

关键词：

Bmp4; atrioventricular septation; cardiogenesis;

D O I：

10.1101/gad.1124803

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.

引用

收藏

页码：2362 / 2367

页数：6

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